Mini-tablets are a great alternative for pellets and granules, because of their relative ease of manufacturing and dosage forms of equal dimensions, weight with smooth regular surface can be produced in a reproducible and continuous way. The main objective of the study was to develop and to evaluate encapsulated mini-tablets systems, in order to achieve desired target product profile for extended period of time. The drug-excipients compatibility study was carried out by FTIR and differential scanning colorimetry DSC. It was also observed that, all the parameters obtained were within specific limit of official compendia and hence complied with the standard. Depending on in-vitro disintegration time and % drug release up to 1 hr it was observed that formulation I3 containing 6% croscarmallose shown optimized result. The sustained release mini tablet into phosphate buffer pH 7.4 released 44.86% to 68.72% drug after 2 hr and the release rate was sustained upto 12th hr with slight variation in release rate. Maximum amount of drug was released by formulation S4 (99.08%). The study concluded that, mini-tablets is better alternative for the administration of different drug in different release pattern.
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